雄の子孫に危険を「警告」する遺伝メカニズム、マウスで発見


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[December 4 AFP] the mouse for an experiment of the male trained so that a specific smell might be feared, The paper to which it is supposed that the shock were shocked in relation to the smell can be told to the posterity of the male produced behind through a certain mechanism in a sperm was published on the 1st at the English science journal “Nature neuroscience (Nature Neuroscience).”
Although the paper claims that ? animal is what brings proof to the opinion that a reaction as if it “inherited” memory of the ancestral trauma (trauma) and he experienced the occurrence is shown, this is discovery of the newest of epigenesis genetics (epigenetics) research.
In epigenetics, even if there is no change of what in the base sequence of DNA which is the basic intelligence of a gene, the environmental agent is mentioned as a factor which begins the behavior from which a gene differs.
“Mr. Brian Diaz (Brian Dias) of one of the coauthors of ? paper, and the U.S. エモリー university medical school (Emory School of Medicine) It is knowing how an ancestor’s experience influencing posterity’s generation, It is said that an understanding about development of symptoms of a 継世代的な nerve psychiatric disorder could be deepened.”
Moreover, it may lead to development of the psychotherapy which can reduce “succession” of memory used as a trauma in the future.
■ Posterity perceives also by a little smells.
The team of Mr. ? Diaz and Mr. Kelley wrestler (Kerry Ressler) of a paper coauthor, When it trained so that the smell similar to the flower of the cherry tree may be feared by giving an electroshock to the leg of a mouse, and 嗅 was carried out in the smell with same posterity of this mouse after that, it was investigated whether the how much frightened reaction would be shown.
Experience which the mouse’s [ and others ] of ? posterity was not in the interior of the womb of a mother mouse yet at the time of training of the original mouse, either, and smelled the smell same before this experiment did not have once, either.
However, the posterity of a mouse in whom Mr. Wrestler received training to coverage of AFP “it was able to perceive and react also by a little smells far.
This said, “Posterity had suggested that susceptibility (to the smell) is high.”
? posterity mouse showed the reaction strong about twice to the smell of the flower of a cherry tree compared with the posterity of the mouse which has not received training.
On the other hand, the same reaction was not shown in another smell.
The gene “M71” inherited from the sperm of the mouse which received ?, next training by posterity was investigated.
Although especially “M71” was a gene which controls the function of the odorant receptor reacted to the smell of the flower of a cherry tree in a nose, in “M71” of a posterity mouse, anything did not have change in the base sequence of DNA.
however — this gene — epigenesis — there was a hereditary trace.
Mr. Diaz says that this trace may change behavior of a gene, may become posterity’s 代, and it may become a cause “further revealed.”
?
? — again — this epigenesis — the hereditary trace made the brain of the posterity of the male mouse which received training, or its male produce a physical change shortly, and the sense-of-smell glomerulus in a cerebral sense-of-smell part was large.
Mr. Diaz explains it as “the body in which, as for this, more M71 nerve cells come to lengthen much more axial fibers (neuronal process) in a nose.”
The posterity who conceived by artificial insemination was also observed using the sperm of the father the same change within ? brain is afraid of the smell of the flower of a cherry tree.
Moreover, change was seen by gene expression also in the sperm of a posterity mouse.
The ? wrestler said, “Such information succession is considered to be one of the effective means for parents “to tell” posterity about the importance of a specific environmental capability with a high possibility that posterity will encounter in a future environment.”
According to Mr. geneticist Marcus pen ブレイ (Marcus Pembrey) of ? Britain, this result of research may be useful for research of a phobia, anxiety disorder, post-traumatic stress disorder (PTSD), etc.
(c)AFP/Mariette LE ROUX




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