男性用経口避妊薬の開発に一歩前進、マウス研究


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[December 4 AFP] in the mouse experiment which aims at development of the oral contraceptive for males (pill), The paper by common teams, such as an Australian モナシュ university (Monash University) which presupposes that the male generative function was succeeded in the experiment made to lose temporarily, It was published at the U.S. science academy bulletin (Proceedings of the National Academy of Sciences, PNAS) on the 3rd.
? team rearranged the gene of the male mouse, and in order that a sperm might move in the inside of genitals, it checked generation of two protein in an indispensable smooth muscle cell.
As a result, even if there is no problem in health and it performed the usual reproduction act, it became a mouse which does not impregnate a scalpel.
By stopping generation of two protein of ? smooth muscle cell, the state where a smooth muscle did not receive the directions “move a sperm” from the inside of a spermatic duct was produced.
As a result, since a sperm does not exist in the semen by which ejaculation was carried out though the sperm was stored in the seminal vesicle of the male mouse, pregnancy does not take place.
The paper says that neither long-term survival of a sperm nor male health is also affected.
The trial about development of a male contraceptive was what is going to target hormone or is going to suppress the function of a sperm until now [ ? ].
These had even a possibility of causing an infertility state long-term and it not only being able to block a male sexual act, but unrecoverable.
By contrast, it is said that it can expect development of the medicine which reproductive ability will recover if there are no long-term side effects and administration is stopped since this research does not influence the sperm formation itself.
? Australian Melbourne — a large (University of Melbourne) — the mackerel of the モナシュ size which tackled research with the English Leicester university (University of Leicester) — Mr. Tino Ventura (Sabatino Ventura), It is supposing that reappearing chemically is the process using gene manipulation the following step in this experiment, and development of the oral male contraceptive says from now on that it will be possible within ten years.
(c)AFP




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