サソリ毒の「痛みを感じない」ネズミ、仕組みを解明 米研究


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[October 25 AFP] ミナミバッタマウス (scientific name: Onychomys torridus) which is one sort of the field mouse which inhabits a desert, In process of the evolution, in order to prey on a scorpion, the paper that the capability to make it not feel the pain of the sting was learned was announced by the U.S. science journal science (Science) on the 24th.
? — paralyzing the violent pain of the sting by the new means for [ this ] surviving using the scorpion which inhabits the southern U.S. and Mexico, and the poison itself which Arizona Burke スコーピオン (Arizona bark scorpion) has.
Research findings are presupposing research teams, such as ? U.S. University of Texas (University of Texas), that the drug company which is searching for the analgetic drug which does not cause dependence may be provided with the attractive subject of research.
According to Mr. Ashley Low (Ashlee Rowe) of University of Texas which commanded ? research, the poison of the Arizona Burke スコーピオン is intense, and if stabbed, it will be said that there is also a possibility of losing one’s life.
“Tobacco with fire is forced on most persons, and they express that as feeling through which it pierces with a nail.
There are some persons who say that it seems that a brand is pushed.”
Grooming of the part stabbed with ミナミバッタマウス with which it was stabbed by ? scorpion “it carries out very much for a short time.
Mr. Low says that it is right [ which left ].”
Moreover, when man was stabbed, it was indicated that a pain probably will not disappear from several minutes for several hours.
? — the research team observed in the experiment what “the number of times of the common rat for an experiment of licking a leg will increase sharply” if the poison of a scorpion is injected into hind legs.
When physiological saline was injected, it was less than the time of the number of times of licking a leg being poison.
Although it was ?, action of ミナミバッタマウス was completely reverse.
The number of times of licking hind legs had more way after physiological saline was injected than the time of poison being poured in fully.
? ミナミバッタマウス disliked the salt solution clearly more than the poison of the scorpion.
■ The poison and NaV1.8 of a scorpion
The “pain” in ? mammals is usually needed in order to survive.
In order that a scorpion may repulse the predatory animal, a partner is burdened with a pain, and one animal is learned from a pain, in order to survive.
In ? mammals, a rapid pain is sent to a brain and a nervous system by the receptor of the pain known as “NaV1.7” and “NaV1.8” of a sodium channel.
As a result of repeating the experiment about ? rat, NaV1.7 was activated in the domestic mouse, but in ミナミバッタマウス, it turned out that it is not activated.
The reason ミナミバッタマウス hardly feels a pain is partially explained by this.
? and also NaV1.8 of ミナミバッタマウス showed the unique action with the poison of the scorpion.
The poison of the scorpion combined with amino acid and it made the near pain receptor calm down.
? ミナミバッタマウス is influence of the poison of a scorpion, and it also loses the feeling of the pain by other causes temporarily at least for a while.
The research findings of ? this time will give a useful hint to the drug company which is groping for the new method of easing a pain.
Mr. Gary Leeuwin (Gary Lewin) of the Max Del Brooke molecular medicine center (Max-Delbruck Center for Molecular Medicine) in ? Germany, The editorial published along with this paper is describing, “, by evolution over millions of years, the organism species with げっ歯 acquired the strategy of the analgesia suitable for oneself.”
“It may enable the designers of a medicine to find the new method of tackling a drug target with an important sodium channel etc. using the natural selection for these years of millions of.”
(c)AFP/Kerry SHERIDAN




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